Abstract
Objective: Secretion of the changes characterizing genetic instability of the gastric mucosa when having esophagus cancer.Methods: 64 patients having esophagus cancer (main group) and 50 patients having gallstone disease were examined. They were undergoing treatment in the hospital No. 1 of the I.M. Sechenov First Moscow State Medical University. In all cases molecular tumor markers in the gastric mucosa after operation and biopsy were examined.Results: Esophagus cancer turned out to be characterized by high frequency of RASSF1А and MLH1 genes methylation and high hTERT, MMP7 and BIRC5 genes expression, and also by high telomerase activity. There was also high frequency of TUSC3, CDH1 and DAPK genes methylation inside gastric mucosa approached to the edge of resection.Conclusions: The study of the frequency of TUSC3, CDH1, DAPK, RASSF1А and MLH1 genes methylation and telomerase activity can be used as clinical markers defining changes in gastric mucosa after its resection concerning cancer.
Highlights
Evaluation of molecular changes in the mucous membrane close to the resection margin after surgical treatment for gastric cancer
The study of the frequency of TUSC3, CDH1, DAPK, RASSF1А and MLH1 genes methylation and telomerase activity can be used as clinical markers defining changes in gastric mucosa after its resection concerning cancer
[Chernousov A, Khorobrykh T, Nemtsova M, Chekunova N, Udilova A, Vychuzhanin D, et al Recurrent gastric cancer in patients undergoing its resection
Summary
Оценка молекулярных изменений в слизистой оболочке, приближенной к краю резекции, после оперативного лечения по поводу рака желудка. Первый Московский государственный медицинский университет имени И.М. Во всех случаях исследовались молекулярные онкомаркеры в слизистой оболочке желудка после операции и биопсии. Для рака желудка оказались характерными высокая частота метилирования генов RASSF1А и MLH1 и высокая экспрессия генов hTERT, MMP7, BIRC5, а также высокая активность теломеразы. Также отмечена высокая частота метилирования генов TUSC3, CDH1 и DAPK в слизистой оболочке, приближенной к краю резекции. Исследование частоты метилирования генов TUSC3, CDH1, DAPK, RASSF1А и MLH1, уровня экспрессии генов hTERT, MMP7, BIRC5 и активности теломеразы можно использовать в качестве клинических маркеров изменений слизистой оболочки желудка после его резекции по поводу рака. Evaluation of molecular changes in the mucous membrane close to the resection margin after surgical treatment for gastric cancer
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