Abstract
A satistically significant decrease in the content of cytochromes P-450 and b5 and in the activity of aniline hydroxylase and p-nitroanisole demethylase occurs in rat liver microsomes during the development of experimental acute fatty hepatosis develoing within a 24-h period after intraperitoneal administration of 125 mg/kg tetracycline hydrochloride. Under these experimental conditions tetracycline hydrochloride elicits only an insignificant disintegrating effect on oxidative phosphorylation in liver mitochondria.
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