EVALUATION OF MICROBIOCENOSIS OF LARGE INTESTINE AND INTESTINAL PERMEABILITY IN OBESE ADOLESCENTS

Abstract

Obesity is one of the most common non−infectious diseases worldwide among both adults and children. It is associated with the development of diseases such as metabolic syndrome, type 2 diabetes, non−alcoholic fatty liver disease, cardiovascular disease etc. The mechanisms proposed to explain the development and progression of obesity include chronic low−intensity inflammation, bacterial translocation, and endotoxemia, which may resulted from dysbiosis and increased intestinal permeability. To study anthropometric parameters, levels of zonulin, lipopolysaccharide, interleukin−6 and interleukin−10, indices of the colon microbiota, 74 adolescents with obesity aged 12−17 years were examined. The correlation analysis of anthropometric and laboratory indices, between anthropometric ones and those of microflora of a large intestine depending on sex was performed. It is noted that obesity is accompanied by the formation of intestinal dysbiosis in 78.2 % of patients with a decrease in the obligate microflora and an increase in the conditionally pathogenic microflora. In adolescent patients, a significant rise in interleukin−6 levels and a tendency to increase interleukin−10 levels compared with adolescents with normal weight, which is a sign of low−intensity inflammation. There was a significant increase in zonulin levels in obese adolescents compared with those in the control group, that may be an evidence of increased intestinal permeability. Positive correlations have been reported between the body weight, abdominal fat distribution, and increased intestinal permeability as well as activation of low−intensity inflammation. In obese adolescents, in the presence of dysbiotic disorders, it is advisable to harmonize the diet and style and correct intestinal dysbiosis with the intestinal barrier restoration of. Key words: zonulin, lipopolysaccharide, interleukins, microbiota, adolescents, obesity.