Abstract
Objective: The objective of the study was to investigate the memory-enhancing activity for erythrinine (ring-c-oxygenated Erythrina alkaloid) from leaf extract of Erythrina indica in mice.
 Methods: The study protocol designed in the way that it was carried out for 21 successive days by administrating the 5 mg/kg, s.c doses of isolated erythrinine to mice and the profile was challenged against the mice feeds with normal saline as a positive control and the mice treated with 5 mg/kg, s.c corticosterone as a negative control for the amnesia using Morris water maze test method.
 Results: Erythrinine-administered mice are showing remarkable retention of the memory (9.07±0.52) on the 21st day as such of the positive control normal saline (10.14±0.22) and against the negative control corticosterone-injected mice (70.86±0.54).
 Conclusions: The dose of 5 mg/kg s.c of isolated erythrinine from the leaf of E. indica shows the remarkable memory enhancement when it was investigated with the memory weakening induced test by corticosterone in mice’s using 5 mg/kg s.c. However, further studies required to elucidate the exact mechanism of action for developing its as potent memory-enhancing drug.
Highlights
Alzheimer’s disease (AD) is a neurological brain disorder
From the source of literature, we found the extract of Erythrina variegate already proved for the memory-enhancing activity and manages the dementia [13]
The study protocol designed in the way it was carried out for 21 successive days by administrating the 5 mg/kg, s.c doses of isolated erythrinine to mice and the profile was challenged against the mice feeds with normal saline as a positive control and the mice treated with 5 mg/kg, s.c corticosterone as a negative control for the amnesia using Morris water maze teat method
Summary
Alzheimer’s disease (AD) is a neurological brain disorder. AD is known as dementia, a group of disorders that impair mental functioning. Memory loss is one of the earliest symptoms, along with a gradual decline of proper thinking abilities called cognitive function and change in personality [1,2,3]. On early stage of the person with Alzheimer disease, may have the symptoms like difficulty in remembering the daily planned activities and misperception (short term memory loss). The disease slowly goes worst such as start forgetting the words, language, loss of motivation, and faced behavioral issue in the society which may gradually isolated from the family and society and as a worst cause leading to death [4,5].
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