Abstract
Evaluation of Membrane Stabilizing, Proteinase and Lipoxygenase Inhibitory Activities of Ethanol Extract of Root and Stem of Sphenocentrum jollyanum Pierre
Highlights
Inflammation can be defined as a cascade of reactions in which the organism’s immune system reacts to invading foreign agents and simultaneously initiate the healing process of any damaged tissue
The result of this study revealed that the extraction yield of the stem and root was 32.00 g and 26.00 g respectively, while the stem extract exhibited a significantly (p
The pathogenesis of different inflammatory diseases has been linked to membrane destabilization of the cells of the immune system, which involves the release of their lysosomal constituents in response to stimuli
Summary
Inflammation can be defined as a cascade of reactions in which the organism’s immune system reacts to invading foreign agents and simultaneously initiate the healing process of any damaged tissue. The pathogenesis of different inflammatory diseases has been linked to membrane destabilization of the cells of the immune system (mast cells, neutrophils, basophils, eosinophils and leukocytes), which involves the release of their lysosomal constituents (myeloperoxidase, serine proteases, phospholipases, and lipoxygenses) in response to stimuli. These degradative enzymes damage endothelial, epithelial cells and destroy connective tissues resulting in different physiological responses which are evident in the classical signs of inflammation (pain, swelling, heat and redness) [3]. According to the report of Gurib-Fakim [12], Mantle et al [13], Annan and Houghton [14], about 80 percent of people in Africa and Asia relies on medicinal plants as alternative to modern medicine in the management of various health disorders
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