Abstract
Purpose To investigate the effect on meibomian gland function of super pulse carbon dioxide (CO2) laser excision in the treatment of eyelid tumors at palpebral margin. Methods 36 patients with 36 eyelid tumor size ≤ 1 cm and within 1 mm to palpebral margin were recruited in this study. Of which, 16 cases with tumors in the upper eyelid and 20 cases in the lower eyelid were involved. The eyelid tumors of all the patients were treated by super pulse CO2 laser with its power density varied between 0.6 and 21.1 W/mm2 and in repeat mode. The laser spot size ranged from 120 to 200 μm. Ocular surface parameters including tear film break-up time (BUT) and meibograde, meibum expressibility, and meibum quality were evaluated at pretherapy, 1 week, 1 month, and 3 months posttherapy in all 36 patients. Result All the patients were satisfied with the therapy. No infective complications and recurrence occurred in any of the 36 patients at the following period. The eyelid wound recovered well with nearly normal appearing after 2 to 3 weeks. The morphology of limbi palpebralis, BUT, meibograde, meibum expressibility, and meibum quality of all the 36 patients showed no significant difference before and after the therapy. Conclusions Super pulse CO2 laser had no effect on meibomian gland function and morphology in the excision of tumors at palpebral margins, which was an efficacy and well-tolerated therapy with lower complications and recurrence.
Highlights
Eyelid benign tumors are common cosmetic concerns and traditionally treated by surgical excision in daily ophthalmology practice
This study demonstrated that super pulse CO2 laser excision showed no significant effect on meibomian gland function in therapy of eyelid benign lesions at palpebral margin, serving as a safe and effective alternative therapeutic modality of traditional surgical excision
Eyelid benign tumors accounted for nearly 80% of eyelid tumors, and not a few proportion was existed at palpebral margins in different types of pathology [11]
Summary
Eyelid benign tumors are common cosmetic concerns and traditionally treated by surgical excision in daily ophthalmology practice. Specific surgical difficulties and complications such as eyelid deformity and scar formation following surgery should be considered in tumors located at palpebral margin. Hyposecretion or obstruction would affect meibomian gland function, even leading to meibomian gland dysfunction. Several iatrogenic conditions such as eyelid surgery and cosmetic procedures were identified and reduced the outflow of lipid secretion because of inadequate gland squeezing, inflammatory obstruction of the opening, and even complete loss of meibomian gland [8,9,10]. Super pulse CO2 laser has been demonstrated superior to other traditional lasers, it has been reported to form atrophic scarring at the treated lesion [4].
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