Abstract
Chitosan (Ch), Poly(DL-lactide-co-glycolide) (DL PLG) and Multiwalled Carbon Nanotubes (MWCNT) were used to fabricate biodegradable porous scaffolds for applications in tissue engineering by thermally induced phase separation (TIPS) technique. Through the use of a Field Emission Scanning Electron Microscopy, the variation in porous morphology was studied. The cumulative results obtained from IR and X-ray diffraction spectra, TGA, DSC and Mechanical properties suggest that there is a chemical interaction between the components of the composite. Also, In vitro cell culture of Wistar rat's osteoblasts were used to evaluate the phenotype expression of cells in the scaffolds, characterizing the viability and alkaline phosphatase (ALP) activity. Moreover, it was confirmed the mineralization of the cells by IR spectra and EDS analysis. Our results thus show that Ch/DL PLG/MWCNT scaffolds are suitable for biological applications.
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