Abstract
Evaluation of Mango Seed Kernel Methanolic Extract on Metalloproteases in Carpet Viper (Echisocellatus) Venom: An in Vitro Experiment
Highlights
Snakebite is a common, devastating environmental, and occupational hazard, especially in rural areas of tropical developing countries like Nigeria
The study was conducted between March, 2014 and June, 2015 at the Department of Biochemistry, Ahmadu Bello University (ABU), Zaria-Nigeria
Freeze-dried E. ocellatus venom was obtained from the Department of Pharmacognosy and Drug Development, Ahmadu Bello University (ABU), Zaria-Nigeria
Summary
Snakebite is a common, devastating environmental, and occupational hazard, especially in rural areas of tropical developing countries like Nigeria. One of the most common poisonous snakes in Nigeria is West African carpet viper (Echis ocellatus) from the Viperidae family It accounts for 90% of bites and 60% of the fatalities in this country, which add up to 20% of all African cases [1,2,3,4,5,6]. This study aimed to evaluate the effect of mango seed kernel methanol extract on metalloproteases in Carpet Viper (Echis ocellatus) venom. Methods: Mango seed kernel methanolic extract was evaluated in vitro for its anti-venom activity and inhibition of metalloproteases of Carpet Viper's (Echis ocellatus) venom. Conclusion: Methanol extract of mango seed kernel has a high affinity for the partially purified enzyme, and it might provide an inexpensive and readily available alternative to sheep serum in the management of snakebite envenomation.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
