Abstract
Animal surface temperature profile captured using infrared camera is helpful for the assessment of physiological responses associated with the regulation of body temperature. Diagnosing breast cancer in early stage itself has a greater effect on the prognosis. In this work, asymmetrical temperature distribution analysis of chemical carcinogen 7,12-dimethyl benz(a)anthracene-induced in the lower right flank region of Wistar rats (n = 6) was carried out to test the potential of thermography in diagnosing mammary cancer and tumor growth over a period of nine weeks in comparison with histopathology results as standard. Temperature difference between the tumor induced lower right and left side of flank region was significant (with P value <0.001), whereas in the abdomen and shoulder there was no significant difference in temperature between right and left sides. Percentage of asymmetrical temperature difference in the tumor induced lower flank region was 0.5 to 2%, whereas in the other regions it was <0.5%. Green pixel distribution in RGB color histogram was asymmetrical in the tumor induced lower flank region. Temperature reduction was observed in the tumor induced region after the seventh day of carcinogen induction. Asymmetrical thermogram analysis is the best method of diagnosing mammary cancer and for studying tumor development.
Highlights
Breast cancer is an uncontrolled growth of breast cells originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules as a result of mutations in the genes responsible for regulating the growth of cells and keeping them healthy
The number of new breast cancer cases is about 100,000 per year and this is expected to rise to 250,000 new cases per year by 2015 [2]
Magnetic resonance imaging (MRI), ultrasonography and fine needle aspiration cytology (FNAC), diagnosis is based on the anatomical changes of the breast, which may take up to ten years for the tumor to grow to a sufficient size to be detectable
Summary
Breast cancer is an uncontrolled growth of breast cells originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules as a result of mutations in the genes responsible for regulating the growth of cells and keeping them healthy. Worldwide 23% (1.38 million) of the total new cancer cases and 14% (458,400) of the total cancer deaths occurred in 2008.The estimated number of new breast cancer cases has been raised from about 641,000 cases in 1980 to 1.6 million cases in 2010 and 625,000 deaths in 2010 [1]. In. India, the number of new breast cancer cases is about 100,000 per year and this is expected to rise to 250,000 new cases per year by 2015 [2]. Regular screening mammograms and computed tomography (CT) itself are cancer carcinogens. Stage diagnosis of breast cancer is very difficult using mammographic screening. Sometimes MRI fails to distinguish between cancer tissue
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