Evaluation of malondialdehyde, total plasma peroxides, total antioxidant capacity and oxidative stress index in gestational diabetes mellitus

Abstract

Oxidative stress has been implicated in the pathogenesis of many pathological cases. it is implicated in both organ and systemic dysfunction. Gestational diabetes mellitus (GDM) is a pathological condition with first onset observed during pregnancy. It causes pregnancy complications and affects 2-7% of pregnant women. For that purpose, this studywas performed with 94 pregnant women with informed consent,51 were diagnosed with GDMand 43 apparently healthy pregnant women. The following parameters were assessed: Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Plasma Peroxide (TPP) and Oxidative Stress Index (OSI). MDA, TPP, and TAC were determined colorimetrically and OSI calculated. Anthropometric indices (weight, height, BMI) and socio-demographic data were determined using standard methods. Data generated were analysed using ANOVA, Student t-test, LSD post hoc and Pearson correlation at P<0.05. The TAC level was significantly higher in control groups (p<0.05), while TPP and OSI were significantly higher in the GDM group compared to control group (p<0.05). A significant negative correlation was observed between TAC and OSI in GDM group (r= -0.486, p=0.005*), and a positive correlation between MDA and BMI, as well as MDA and Age in GDM group (r=0.527, p=0.002* and r=0.375, p=0.034* respectively). GDM patients tend to have a higher TPP level and decreased TAC which may enhance the pathogenesis or pathophysiology of these conditions.