Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India

Gunasekaran Kasinathan,Manju Rahi,Sudhansu Sekhar Sahu,Subramanian Swaminathan,Jambulingam Purushothaman,Vijayakumar Tharmalingam

doi:10.1186/s12936-019-2692-3

Abstract

BackgroundMAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alpha-cypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets. The bio-efficacy of MAGNet LN was reported to be high even after 25 washes. The LN met the WHO criteria of Phase I evaluation and obtained recommendation from the World Health Organization Pesticide Evaluation Scheme (WHOPES) for Phase II trial. For registration of the LN in India, the current study was conducted to evaluate its efficacy after 20 or 25 washes compared to negative control (untreated net) and positive control (Duranet LN) in experimental huts against a wild, free flying pyrethroid susceptible population of Anopheles fluviatilis in terms of deterrence, blood-feeding inhibition, mortality and induced exophily.MethodsThe evaluation was carried out in six experimental huts located at Kandhaguda village in Malkangiri district, Odisha state following the WHO guidelines.ResultsThe study showed that 25 times washed MAGNet LN produced 100% mortality in cone bioassays before and after hut evaluation. MAGNet washed 25 times did not differ significantly from all other treated nets in terms of deterring hut entry, induced exophily, blood feeding inhibition and causing mortality of An. fluviatilis.ConclusionsMAGNet LN showed extended wash resistance retaining its bio-efficacy up to 25 washes and met the WHOPES requirement of passing Phase II evaluation.

Highlights

IntroductionMAGNet long-lasting insecticidal net (LN) is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alphacypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets
MAGNet LN is a wash resistant long-lasting insecticidal net (LLIN) in which the alphacypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets
The objective of the study was to evaluate the efficacy of MAGNet LN against the pyrethroid susceptible vector, An. fluviatilis, detailed analysis of data was carried out for this vector species only

Summary

Introduction

MAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alphacypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets. The bio-efficacy of MAGNet LN was reported to be high even after 25 washes. Kasinathan et al Malar J (2019) 18:59 households after distribution for retreatment was the main operational challenge in large-scale implementation of ITNs [7]. To overcome this problem, use of long-lasting insecticidal nets (LLINs) has been encouraged by the World Health Organization (WHO) and extended to hard core malarious areas since last one decade [5]. LLINs usually retain insecticidal bio-efficacy for 3 years without re-treatment and withstand 20 washes [8]. Only a few LNs (LN indicates a particular brand as approved by the WHO), which claim to withstand more than 20 washes have been put under different phases of evaluation [9]

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