Abstract
Clarithromycin, midecamycin and tylosin effectively provided selective pressure for maintenance of a macrolide, lincosamide and streptogramin B resistance (MLSr) plasmid in Clostridium acetobutylicum ATCC 824 at pH values as low as 4.5, whereas erythromycin, oleandomycin, spiramycin, lincomycin and clindamycin did not. Furthermore, clarithromycin, midecamycin and tylosin were not degraded by late stationary-phase ATCC 824 fermentation fluids. Solvent formation, but not acid formation. was inhibited by tylosin but not by clarithromycin in an MLSr plasmid containing strain. Clarithromycin should therefore be useful for the maintenance of selective pressure for MLSr plasmids in low pH recombinant C. acetobutylicum ATCC 824 fermentations.
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