Abstract
INTRODUCTION- Macrocytosis is a relatively common nding in routine CBC and peripheral blood smear. It is divided into two groups– megaloblastic and non-megaloblastic groups based on morphological and biochemical ndings. MATERIALS AND METHODS-We conducted this study in the department of pathology, Nalanda medical college, Patna, Bihar over a period of 18 months (September 2018 to March 2020). Sixty adult patients (>18 years) with macrocytosis (MCV>100) were evaluated in our study. Various tests were done to establish the cause of macrocytosis. RESULT– The most common cause of macrocytosis was megaloblastic anemia due to vitamin B deciency (53.3%). Non-megaloblastic anemia 12 was caused by liver disorder (18.33%) followed by primary bone marrow disorders (10%). CONCLUSION- The commonest cause of macrocytosis is megaloblastic anemia, but there are multiple non-megaloblastic causes with different mechanism and different treatment approach. Early detection of macrocytosis and its etiology helps in proper management of the patient with better outcome.
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