Abstract
This study was undertaken to evaluate the effects of Mass Drug Administration (MDA) on Wuchereria bancrofti (microfilariae) after two rounds of combined Ivermectin and Albendazole distribution. A total of 221 participants were recruited in three communities in Lau Local Government Area of Taraba State by convenience sampling method. Questionnaires and physical examinations were used to assess clinical manifestations associated with the infection. Blood samples were collected by finger prick method and stained with Giemsa stain for examination to establish the presence of W. bancrofti while immunochromatographic card test was performed to determine the presence of filarial antigen in serum. Previous data were used to determine the pre-drug prevalence of the parasite. The results showed that the drug did not significantly reduce the clinical manifestations reported among the patients. The microfilariae prevalence and microfilaria mean density after two rounds of drug administration was 19.5% and 1.49%, while the pre- MDA prevalence and microfilaria mean density was 27.8% and 2.44% respectively. There was a statistically significant decrease of microfilaria prevalence (P<0.05) after two rounds of MDA. There was no significant effect of MDA by age, sex and occupation-related microfilariae prevalence in the study area. In conclusion, the study reveals that microfilaria prevalence and load decreased after two rounds of MDA of combined Ivermectin and Albendazole distribution amongst the studied populations. Routine evaluation of the MDA is required to assess the impact of the drug for the eventual elimination of the infection.
Highlights
ObjectivesOne of the objectives of this study was to evaluate the efficacy of Mass Drug Administration (MDA) on clinical manifestation indicative to LF, the findings
In Africa, 34 countries are endemic, and Nigeria was rated as the third most endemic country with lymphatic filariasis in the world after India and Indonesia
There was no statistical significant odd of decrease of clinical manifestations observed among patients with lymphedema, hydrocele and ADL (Odd Ratio 1.00) among the studied population (Table 1)
Summary
One of the objectives of this study was to evaluate the efficacy of MDA on clinical manifestation indicative to LF, the findings
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