Abstract
The growth velocity (GV, cm/y) induced by hGH treatment was evaluated in 85 hGH deficient patients classified into 4 groups. Gr. A: Isolated hGH deficiency (IGHD), males, n=22; age at start of therapy (age): 0.8-19.6 y (m=9.6y). Gr. B: IGHD, females, n=19; age 0.4-16.9 y (m=8.6 y). Gr. C: Multiple pituitary hormone deficiencies (MPHD), males, n=30; age 1.3-21.4 y (m=11.7 y). Gr. D: MPHD, females, n=14; age 2.5-18.3 y (m=10.3 y). Follow-up ranged from 1-12 y with actual treatment amounting to 40-60% of the time. Treatment was given in courses of 3-24 months, 2-6 U×3/wk with intervals of 2-14 mos. The regression equation of GV (cm/y) as a function of age and age2 was calculated using program BMDP2R (Dixon & Brown, 1979). The formula is:This formula enables the evaluation of long term response to hGH comparing expected and observed growth velocity.
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