Abstract
Vaccination is one of the control measures of the disturbing Newcastle Disease in Egypt. InactivatedNewcastle Disease virus (NDV) vaccine was prepared using a local isolate (NDV-ch-EG-CLEVBF604-2016), from Qaliobia governorate, Egypt, with Montanide ISA70VG as an oil adjuvant. Theprepared vaccine was evaluated in comparison with an inactivated imported vaccine. Chick andTurkey chick groups vaccinated with either prepared or imported vaccines showed high serumantibody titers from the 3rd week post vaccination and reached the highest titer at the 9th week postvaccination using HI test. Both prepared and imported vaccines gave near percentage of protectionagainst the local and the classical strain in both groups of chicks and turkeys ,21 days postvaccination, with no clinical signs or lesions on examination. Concluding that the locally preparedinactivated NDV vaccine can protect chicken and turkey against both homologous and heterologouschallenging viruses.
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