Evaluation of liver functional test values in women with intrahepatic cholestasis of pregnancy

Abstract

Introduction. Intrahepatic cholestasis of pregnancy is a liver disease, the diagnosis of which is based on the assessment of serum bile acid levels and liver function tests. The study aimed to assess liver function test values in women with intrahepatic cholestasis of pregnancy. Materials and methods. The study was based on a prospective cohort study of 142 clinical cases, divided into two groups according to the complication of pregnancy with cholestasis gravidarum. The research was carried out by assessing the level of liver function tests as well as by studying medical documentation. Statistical data were processed using IBM Statistics SPSS 21, MedCalc and GraphPad software. To assess sensitivity and specificity in examining model efficiency, the ROC curve was used. Results. Increased ALT and AST values were found in women with intrahepatic cholestasis of pregnancy. Alkaline phosphatase and γ-glutamyltransferase values were increased in an insignificant number of pregnant women with cholestasis gravidarum. Based on ROC curves, the sensitivity of ALT indicator in diagnosis of intrahepatic cholestasis of pregnancy was 81.7%, specificity - 81.7%; for AST the sensitivity of the indicator was 80.3%, specificity - 81.7%. Conclusions. In the study it was demonstrated significant increase of ALT and AST values in women with cholestasis gravidarum, as well as high sensitivity and specificity of these indicators in the diagnosis of intrahepatic cholestasis of pregnancy.