Evaluation of Liver Functional Test (LFT) and Kidney Functional Test (KFT) in Dengue Patients

Abstract

Background: Dengue is an acute infection caused by an arbovirus in the Flavivirus genus, and the mosquito Aedes aegypti is the vector. Case fatality ratio in India is reported to be 3 to 5 percent. One of the least studies complications occurring in dengue is acute kidney injury (AKI) and liver abnormalities are few of the least studied complications of dengue. Hence, we planned the present study to assess the LFT and KFT in Dengue patients. Methods: The present study included assessment of 100 patients out of which 50 patients were found to be sero positive for dengue while rest 50 were found to be sero negative. Assessment of levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the degree of hepatic involvement was done in all the patients included in the present study. AKIN definition for classification of AKI (Acute kidney injury) Stages was used for the present study. All the results were analyzed by SPSS software. Results: Total proteins level among dengue sero positive and negative subjects was found to be 7.01 and 7.89 g/dl. Significant results were obtained while comparing the total proteins levels among dengue positive and negative subjects. While comparing the albumin and globulin levels between dengue positive and negative subjects, significant results were obtained. Significant results were obtained while comparing the AST and ALT levels between both the study groups. 14.5 And 63.5 percent of the patients were AKI and AKIN- 1 AKI. Conclusions: Hepatic and renal involvement occurs in patients suffering from dengue fever.