Abstract
In order to improve the care given to patients in austere environments, we have conducted research to identify and test liquid topical antimicrobials. Though well proven in efficacy, antimicrobial creams are difficult to use in austere environments for numerous reasons. In order to rigorously test these agents, we used the Walker-Mason rat scald model with a 20% TBSA full thickness injury inoculated with P. aeurginosa. The maturity of products assessed included agents with FDA approval for other indications as well as candidates in various stages of pre-clinical testing. Here we report the results of this testing to date, and the trends observed when testing various agents in this established model. Antimicrobials were obtained from commercial sources if available, or by materials transfer agreement with the developer when required. Agents tested were: 85mg/g Mafenide Acetate Cream, 5% Mafenide Acetate Solution, 5% Mafenide HCl solution, 1%, 5% and 10% Proprietary Antimicrobial Compound...
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