Abstract
Alzheimer’s (AD) and Parkinson’s (PD) are respectivamente chronic, progressive and incurable neurodegenerative diseases. AD is one of the most common forms of dementia and is related to the loss of cognitive function, memory Affecting, language and behavior. PD, in turn, Mainly Affects motor coordination, tremors Causing and Difficulties in movement. The diagnosis is based on the patient’s clinical history and behavioral observation, Which manifests in later stages of the disease. Magnetic resonance tomography and help in the investigation and exclusion of other pathologies. When other hypotheses are excluded, the doctor can confirm the diagnosis Then. It is called the differential diagnosis. In the search for more precious methods to investigate These diseases, diseases. Research on the socalled biomarkers CFS has shown promise and has a strong potential for clinical application in the near future, contributing to the advancement of medicine and the consequent improvement in the treatment of its carriers.
Highlights
Alzheimer’s is a neurodegenerative disease that affects mostly older people, causing a lot of impairments mainly in memory and language, in addition to Alzheimer’s disease (AD), Parkinson’s disease fits under the same circumstances, the second neurodegenerative disease most common, its most obvious clinical signs are tremors
Many studies are being conducted on new discoveries for early diagnosis of the same, in order to offer a better quality of life for their patients, since most of the time the diagnosis is made based on clinical manifestations, which implies greater loss of neurons because symptoms may appear later such as in Parkinson’s disease (PD) for example
This study sought to answer the problem: “What is the purpose of the search for biomarkers for early diagnosis of Alzheimer’s and Parkinson’s? The overall objective of the study was to evaluate the cerebrospinal fluid of uses for the diagnosis of Alzheimer’s and Parkinson’s
Summary
Alzheimer’s is a neurodegenerative disease that affects mostly older people, causing a lot of impairments mainly in memory and language, in addition to Alzheimer’s disease (AD), Parkinson’s disease fits under the same circumstances, the second neurodegenerative disease most common, its most obvious clinical signs are tremors. In short Alzheimer’s disease has characteristic pathophysiological factors, which are: microglial activation, deposition of amyloid beta peptide (Aß), herpofosforilação of Tau protein, synaptic plasticity inadequate From these conditions, Alzheimer’s diagnosed patients have some common symptoms such as difficulty in remembering recent conversations, places, events, or names, apathy and depression, early stage considered manifestations, while the late symptoms are characterized by disorientation, impaired communication, amended trial , mood swings and personality, mental confusion, difficulty speaking, swallowing and walking. Alzheimer’s diagnosed patients have some common symptoms such as difficulty in remembering recent conversations, places, events, or names, apathy and depression, early stage considered manifestations, while the late symptoms are characterized by disorientation, impaired communication, amended trial , mood swings and personality, mental confusion, difficulty speaking, swallowing and walking Risk factors such as, gender, genetic inheritance, depression, low education, diseases related to the disease (diabetes, dyslipidemia, obesity and hypertension) and lifestyle collaborate significantly to the increasing incidence of Alzheimer. Studies indicate that the characteristic motor symptoms of the disease may start decades after the cellular and molecular neuropathological symptoms, DP predominates in males aged 50 to 65 years, when
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