Evaluation of Left Ventricular Synchronicity in Hypertensive Patients With Overweight or Obesity

Abstract

The left ventricular synchronicity in hypertensive patients with overweight or obesity has not been well elucidated. This study was designed to evaluate the left ventricular synchronicity in these patients. Tissue Doppler imaging was performed in 126 hypertensive patients and 25 control subjects. The hypertensive patients were divided into three groups according to BMI: normal weight group (BMI <25 kg/m(2), n = 32, H-NW group), overweight group (BMI 25-29.9 kg/m(2), n = 64, H-OW group), and obese group (BMI >or=30 kg/m(2), n = 30, H-OB group). Left ventricular systolic and diastolic synchronicity were determined by measuring the maximal differences in time to peak myocardial systolic contraction (T(s)-diff) and early diastolic relaxation (T(e)-diff) between any two of the left ventricular segments and the standard deviation of time to peak myocardial systolic contraction (T(s)-SD) and early diastolic relaxation (T(e)-SD) of all 12 segments. Compared with the control group, the indexes of synchronicity including T(s)-diff, T(s)-SD, T(e)-diff, and T(e)-SD were significantly prolonged in the hypertensive patients. Furthermore, although the indexes of blood pressure had no difference among the hypertensive groups, the impaired systolic and diastolic synchronicity including T(s)-diff, T(s)-SD, and T(e)-SD was obviously aggravated with the increasing BMI. Stepwise multivariate analysis revealed BMI as an independent predictor of T(s)-SD and T(e)-SD. Therefore, the impairment of left ventricular synchronicity was aggravated with increasing BMI in hypertensive patients. Overweight and obesity may be important factors to impact the left ventricular synchronicity.