Abstract
Objective To evaluate left ventricular(LV) global and regional systolic function by three-dimensional speckle tracking imaging(3D-STI) in patients with systemic lupus erythematosus (SLE). Methods Twenty-two patients with SLE were selected randomly as SLE group and twenty-two healthy people were included as control group. 3D-STI was performed in all participants to get global and regional strain parameters, including global longitudinal peak systolic strain(GLS), global circular peak systolic strain(GCS), global radial peak systolic strain(GRS), global area peak systolic strain(GAS), segmental longitudinal peak systolic strain (SLS), segmental circumferential peak systolic strain (SCS), segmental radial peak systolic strain (SRS), and segmental area peak systolic strain (SAS). The sensitivity and specificity of GCS and GAS reflecting LV systolic function in patients with SLE were analyzed under the receiver operating characteristic (ROC) curve. Results ①The global strain: compared with the control group, GCS and GAS decreased significantly in SLE group (P 0.05). ②The regional strain: compared with the control group, the SCS in segments of basal anteroseptal, basal inferoseptal, mid anterior, mid inferosptal, mid anterolateral, apical inferior, apical lateral decreased significantly in SLE group. The SAS of basal anterior, basal inferoseptal, mid inferosptal, mid anterolateral, apical anterioe, apical lateral decreased significantly in SLE group (P<0.01). The SCS in segments of apex and the SAS of mid anterior, apical septal, apex decreased in SLE group (P<0.05). ③The ROC curve: the sensitivity and specificity of GCS on detecting the LV systolic dysfunction were 59.1% and 87.5%, and those of GAS were 77.3% and 83.3%, respectively. Conclusions 3D-STI is a convenient and accurate way to early detect LV global and regional systolic dysfunction in SLE patients. Key words: Echocardiography, three-dimensional; Lupus erythematosus, systemic; Ventricular function, left; Three-dimensional speckle tracking imaging
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