Evaluation of left atrial volume and functions by 3D echocardiography in patients with prediabetes and investigation of its correlation with NT-pro ANP levels

Abstract

Aim: An increased burden of cardiovascular disease is observed in prediabetes compared to normoglycemic. In this study, we aimed to evaluate left atrium (LA) volume indices and mechanical functions in prediabetes patients by real-time three-dimensional echocardiography (3DE) and examine the relationship of these parameters with N-terminal pro-atrial natriuretic peptide (NT-pro-ANP) levels.Methods: 41 patients diagnosed with prediabetes by the oral glucose tolerance test in the endocrinology outpatient clinic and 43 healthy controls were included in this study. We evaluated the volume indices and mechanical functions of the LA using 3DE. Plasma NT-proANP was evaluated by the enzyme-linked immunosorbent assay method.Results: Median NT-pro-ANP level was higher in the prediabetes group than the control group (1.5 vs 0.7 nmol/L, p