Abstract
BackgroundCryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to the rapid detection of cryptococcal antigens.MethodsStudies were retrieved systematically from the Embase, PubMed, Web of Science, and Cochrane Library before July 2019. The quality of the studies was assessed by Review Manager 5.0 based on the Quality Assessment of Diagnostic Accuracy Study guidelines. The extracted data from the included studies were analyzed by Meta-DiSc 1.4. Stata 12.0 software was used to detect the publication bias.ResultsA total of 15 articles with 31 fourfold tables were adopted by inclusion and exclusion criteria. The merged sensitivity and specificity in serum were 0.98 and 0.98, respectively, and those in the cerebrospinal fluid were 0.99 and 0.99, respectively.ConclusionsCompared to the urine and other samples, LFA in serum and cerebrospinal fluid is favorable evidence for the diagnosis of cryptococcosis with high specificity and sensitivity.
Highlights
Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans
Cryptococcus genus is based on C. neoformans, C. deneoformans, C. gattii, and other nonpathogenic
C. gattii and C. neoformans are responsible for almost all cryptococcal infections in humans
Summary
Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Cryptococcus genus is based on C. neoformans, C. deneoformans, C. gattii, and other nonpathogenic. Those strains of serotype A or var. Grubii are considered to be C. neoformans and serotype D or var. C. gattii and C. neoformans are responsible for almost all cryptococcal infections in humans [2]. In 2014, the number of cryptococcal antigen-positive people worldwide was 278,000, and the global incidence of cryptococcal meningitis was 223,100. Annual global deaths from cryptococcal meningitis were estimated at 181,100 and 135,900 deaths in sub-Saharan Africa and 15% of AIDS-related deaths
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