Evaluation of laboratory parameters in febrile seizure types

Abstract

Background & Objectives: Febrile seizures (FS) are the most common neurological emergencies in childhood. The differentiation of FS types is generally evaluated based on the clinical features of the seizure, and there is currently no laboratory test to guide this process. In this study, the relationship between FS types and laboratory tests was examined and the power of these parameters in differential diagnosis was investigated. Methods: In this retrospective study, a total of 184 cases were evaluated in three groups: simple FS (n:107), complicated FS (n:35), and control group (n:42). At the time of admission; hemogram, biochemical and blood gas analysis, prolactin, cortisol values, and laboratory indices were examined in terms of diagnosis. Results: Among the groups; sodium (Na), glucose (G), Glucose/potassium ratio (GPR), C-reactive protein (CRP), white blood cells (WBC), platelet count (PLT), neutrophil count (N), neutrophil/lymphocyte ratio (NLR), lymphocyte count (L), mean platelet volume (MPV), MPV/PLT ratio (MPR), Hb, Htc, lactate, prolactin, and cortisol have a statistically significant difference in values (p<0,05). If the simple FS and complicated FS groups were compared, a statistically significant difference was found between sodium, GPR, NLR, MPR, lactate, prolactin, and cortisol values (p<0.001). In the ROC curve analysis, it was determined that there was the good and excellent diagnostic ability for these parameters. Conclusion:This study is one of the few studies investigating the relationship between FS types and laboratory parameters. We think that sodium, GPR, NLR, MPR, lactate, prolactin, and cortisol levels will help to differentiate FS types.