Abstract
Purpose of the study Tenofovir (TFV) disoproxil fumarate (TDF) is an oral prodrug of the nucleotide reverse transcriptase inhibitor TFV. Following oral administration, TDF undergoes rapid conversion to TFV in plasma. TFV is eliminated from systemic circulation renally through a combination of glomerular filtration and active tubular secretion. Active tubular secretion of TFV has been inferred from the observation that TFV renal clearance exceeds that of creatinine clearance in patients. Renal drug-drug interactions may occur between therapeutics that are substrates for the same tubular transport pathways or that inhibit the pathway of a drug subject to renal excretion: both of them, ritonavir (RTV) and tenofovir, share the same transport pathways (MRP4) [Ray et al. Antim Ag Chem 2006 (Oct); 50: 3297– 3304]. The objective of the present study was to investigate in a real clinical setting the relationship between PI/r co-administration with TDF and changes in estimated renal function.
Highlights
Evaluation of kidney toxicity in HIV patients with tenofovir-based regimen: the role of boosted protease inhibitor in real clinical setting
Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
TFV is eliminated from systemic circulation renally through a combination of glomerular filtration and active tubular secretion
Summary
Evaluation of kidney toxicity in HIV patients with tenofovir-based regimen: the role of boosted protease inhibitor in real clinical setting F Ortu*, P Piano, P Serra, R Meleddu, N Corso and PE Manconi Address: Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy * Corresponding author from Ninth International Congress on Drug Therapy in HIV Infection Glasgow, UK.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
