Evaluation of kidney disease using e-GFR compared to measured creatinine clearance

SP Tejaswi Pullakanam,Department Of Biochemistry, Gayatri Vidya Parishad Institute Of Health Care And Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India ,Barla Krishna,Nakka Madhuri,Priya K. Dhas,Nekkala Ramakrishna,Department Of Biochemistry, Gayatri Vidya Parishad Institute Of Health Care And Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India ,Department Of Biochemistry, Gayatri Vidya Parishad Institute Of Health Care And Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India ,Department Of Biochemistry, Vinayaka Missions Kirupananda Variyar Medical College And Hospitals, Salem, Tamilnadu, India ,Department Of Biochemistry, Gayatri Vidya Parishad Institute Of Health Care And Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India

doi:10.6026/973206300200229

SP Tejaswi Pullakanam, Department Of Biochemistry, Gayatri Vidya Parishad Institute Of Health Care And Medical Technology, Marikavalasa, Visakhapatnam, Andhra Pradesh, India

Open Access

https://doi.org/10.6026/973206300200229

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Journal: Bioinformation	Publication Date: Mar 31, 2024
License type: cc-by

Abstract

Measurement of renal function is required for diagnosis and stratification of kidney disease. GFR is considered as the best overall measure of kidney function for diagnosis and treatment of patients with CKD. Measuring GFR is time consuming and hence eGFR is calculated using equations with endogenous markers like SCr. Therefore, it is of interest to examine the accuracy of creatinine based estimates (CrCl and CG formula) of GFR among patients. Thus, 60 in-patients (30 men and 30 women) at the GVP hospital and 40 controls were enrolled in the study. SCr and 24 hrs urine creatinine are estimated using blood sample and same day 24-hr urine collection. SCr is estimated using the Kinetic Jaffe’s method in Auto analyzer for serum and urine. eGFR is calculated using the CG formula for the SCr value. We evaluated the correlation between measured CrCl derived from 24-hr urine collection and calculated/predicted CrCl using the CG equations. A positive correlation was observed between measured GFR and e-GFR in case and control groups.

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