EVALUATION OF Ki-67 IN PROSTATIC CARCINOMA AND ITS CORRELATION WITH GLEASON'S SCORE AND OTHER PROGNOSTIC FACTORS

Abstract

Background&Objectives: Prostate cancer is the second most commonly diagnosed malignancy and sixth leading cause of cancer death among men globally. Gleason system is the one recommended by World health organization and accepted by majority of urologists and radiotherapists. Proliferation marker Ki-67 reects the tumor cell proliferation rate as it correlates with progression, metastasis and prognosis in a number of different malignancies. The objective is to assess different histopathological grades and ki67 protein expression in prostate carcinoma and to correlate ki67 with Gleason's grade and other prognostic factors. Methods: The Prospective study was carried out in the Department of Pathology of SRMSIMS, Bareilly over a period of 1.5 years from November 2019 to April 2021.47 histologically conrmed prostatic carcinoma cases were included. They were subjected to immunohistochemical staining for ki67 and its activity was quantied using the labeling index. Result: In this study, expression of ki67 was markedly high in tumours with increased Gleason's grade group and was found to be statistically signicant( p value= 0.042). No statistically signicant correlation was seen with USG ndings, S. PSA, lymphovascular and perineural invasion.(p value= 0.452, 0.587, 0.051, 0.320). Interpretation&Conclusion: Ki67 expression is signicantly upregulated in aggressive and high grade prostatic carcinomas which reects its crucial relationship with the prognosis of these cancers.