Abstract
Background&Objectives: Prostate cancer is the second most commonly diagnosed malignancy and sixth leading cause of cancer death among men globally. Gleason system is the one recommended by World health organization and accepted by majority of urologists and radiotherapists. Proliferation marker Ki-67 reects the tumor cell proliferation rate as it correlates with progression, metastasis and prognosis in a number of different malignancies. The objective is to assess different histopathological grades and ki67 protein expression in prostate carcinoma and to correlate ki67 with Gleason's grade and other prognostic factors. Methods: The Prospective study was carried out in the Department of Pathology of SRMSIMS, Bareilly over a period of 1.5 years from November 2019 to April 2021.47 histologically conrmed prostatic carcinoma cases were included. They were subjected to immunohistochemical staining for ki67 and its activity was quantied using the labeling index. Result: In this study, expression of ki67 was markedly high in tumours with increased Gleason's grade group and was found to be statistically signicant( p value= 0.042). No statistically signicant correlation was seen with USG ndings, S. PSA, lymphovascular and perineural invasion.(p value= 0.452, 0.587, 0.051, 0.320). Interpretation&Conclusion: Ki67 expression is signicantly upregulated in aggressive and high grade prostatic carcinomas which reects its crucial relationship with the prognosis of these cancers.
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