Abstract
Background Mammary tumors of dogs are an excellent model to investigate the clinical and pathological diagnosis and prognosis of cancer. Interleukins play a key role in cancer, particularly interleukin-8, which has tumorigenic and pro-angiogenic properties and interleukin-12, with anti-metastatic and angiogenic properties. The carbohydrate antigen tumor marker (CA 15-3) has important clinical significance in the monitoring of patients with breast cancer and, in addition, free circulating DNA has been considered a candidate biomarker for cancer. The aim of this study was to measure serum levels of interleukin-8, 12, CA 15-3 and to estimate the number of copies of CAN SINE sequences to correlate with clinicopathological parameters and survival.
Highlights
Mammary tumors of dogs are an excellent model to investigate the clinical and pathological diagnosis and prognosis of cancer
Interleukins play a key role in cancer, interleukin-8, which has tumorigenic and pro-angiogenic properties and interleukin-12, with anti-metastatic and angiogenic properties
The aim of this study was to measure serum levels of interleukin-8, 12, CA 15-3 and to estimate the number of copies of CAN SINE sequences to correlate with clinicopathological parameters and survival
Summary
Mammary tumors of dogs are an excellent model to investigate the clinical and pathological diagnosis and prognosis of cancer. Interleukins play a key role in cancer, interleukin-8, which has tumorigenic and pro-angiogenic properties and interleukin-12, with anti-metastatic and angiogenic properties. The carbohydrate antigen tumor marker (CA 15-3) has important clinical significance in the monitoring of patients with breast cancer and, in addition, free circulating DNA has been considered a candidate biomarker for cancer. The aim of this study was to measure serum levels of interleukin-8, 12, CA 15-3 and to estimate the number of copies of CAN SINE sequences to correlate with clinicopathological parameters and survival
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