Evaluation of interleukin-6 and C - reactive protein as a inflammatory mediators in type 2 diabetic subjects in Indian population of Bhopal

Abstract

India leads the world with the largest number of Diabetic subjects, hence can be called as Diabetic Capital of World. Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. The researches in past decade have revealed a critical link between metabolic disorders and inflammation which leads to a concept called metaflammation. The linkage of inflammation and type 2 diabetes mellitus (T2DM) has been extensively investigated for over a decade. The main objective of the study is to assess inflammatory markers in T2DM subjects by measuring cytokines and acute phase proteins and its comparison with healthy controls. Total 100 subjects were studied which were divided into two groups of 100 of Diabetic cases and 100 Healthy controls after defining proper inclusion and exclusion criteria. Gender wise distribution was also done. FPG, 2H-PG, HbA1C and CRP were estimated on fully automated analyzers while IL-6 was estimated by ELISA. The result had shown that cases have significantly elevated IL-6 and CRP when compared to age and sex matched healthy controls with p<0.0001. FPG, 2H-PG and HbA1c was also significantly elevated in cases as compared to healthy subjects. We had also compared inflammatory and glycemic markers on the basis of gender. We can conclude that in developing countries like India estimation of inflammatory markers along with glycemic markers can predict secondary complications of disease.