Abstract
The aim of this work was to prepare hybrid organo-layered materials using intercalation process then evaluated them as a drug release and antibacterial materials. Four kinds of organo-layered materials cetyltrimethylammonium bromide-bentonite (CTA-bent), ampicillin-bentonite (AMP-bent), CTA-magadiite (CTA-mag) and ampicillin-magadiite (AMP-mag) have been prepared and characterized using several techniques. The results showed that the CTA and AMP molecules are incorporated between the interlayer spaces, subsequently leading to an increase of the basal spacing of bentonite and magadiite solids, in which preserving their two-dimensional character. Antibacterial activities of the intercalated layered materials were determined against Gram positive and Gram negative bacteria. The ranking of antibacterial activity of the intercalated materials was as organo-modified bentonite > organo-modified magadiite. In vitro drug release profile in simulated intestinal fluid pH 7.4 at 37 °C was evaluated. A satisfactory percent of cumulative AMP release from AMP-bent was observed. The cumulative drug release from AMP-bent and AMP-mag was 31.13% and 25.24%, respectively. This work highlighted the role of the natural surface of layered materials in the release of a drug by involving surface-drug interaction forces.
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