EVALUATION OF INSULIN RESISTANCE AND LIPID PROFILE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. It is associated with dyslipidemia and Insulin resistance which is a high risk factor for cardiovascular disease in the long-term. Objectives:Aim of study to determine Insulin Resistance, lipid prole, ApolipoproteinA1 and Apolipoprotein- B levels in women with polycystic ovary syndrome. Study Design: Hospital based observational case control study. Method: We evaluated 80 polycystic ovary syndrome women as cases and age matched 80 women as controls visited to obstetrics and gynaecology OPD at NDMC Medical College and Hindu Rao Hospital, Delhi, India. The case selection was done according to Revised Rotterdam criteria (2003). Lipid parameters, Apo lipoprotein -A & Apo lipoprotein -B. Fasting blood sugar and fasting Insulin were measured. Insulin resistance (IR) was calculated by the HOMA-IR formula. Results: The present study showed signicantly higher values of triglycerides ( 48%) , HDL-C(46.95 ± 10.21mg% ) ,fasting glucose (25%) and IR (10 %)in case than control (8%, 41.78 ± 9.71 mg% , 7% and 5% respectively) and signicantly low value of Apo lipoprotein-A (45%) in PCOS women than controls (1.25%).Whereas the values of Total cholesterol, LDL-C, VLDL-C, Apolipoprotein B, fasting insulin ,TC/HDL and LDL/HDL ratios was not signicantly different between two groups. Conclusion: In the present study PCOS women had hypertriglyceridemia and raised IR whereas Apo lipoprotein -A was found low. These parameters are considered as high risk factors for cardiovascular disease. Early and regular screening of PCOS women can prevent progression of cardiovascular diseases.