Evaluation of inflammatory markers and mean platelet volume as short-term outcome indicators in young adults with ischemic stroke

Ahmed Dahshan,Asmaa M Ebraheim,Laila A Rashed,Ahmed T El Ghoneimy,Mohammed A Farrag

doi:10.1186/s41983-019-0123-6

Abstract

BackgroundStudying outcome predictors in patients with onset of cerebral infarction in early adult life may enhance our knowledge of disease pathophysiology and prognosis.AimThe aim is to identify independent predictors of short-term outcome of first-ever ischemic stroke in young adults with special emphasis on inflammatory and thrombogenic markers.MethodsWe enrolled 33 patients aged 19–44 years with first-ever ischemic stroke admitted to Kasr Alainy Stroke Unit and 33 matched controls. Clinical, radiological, and laboratory (adhesion molecules, C-reactive protein, prolactin, and mean platelet volume) evaluations were carried out. Functional outcome at 7 days after stroke onset was assessed using the modified Rankin scale, and independent predictors were identified.ResultsThe most frequently identified risk factor was cardiac abnormality. Patients exhibited significantly higher levels of baseline inflammatory and thrombogenic markers compared with controls. These markers were significantly correlated with the stroke severity. Logistic regression model showed that high National Institutes of Health Stroke Scale (NIHSS) score (odds ratios [OR] = 0.13; 95% confidence interval [CI], 0.04–0.24; P = 0.01) and large infarction size (OR = 0.11; 95% CI, 0.09–0.17; P = 0.04) but not the laboratory markers were independent predictors of unfavorable outcome.ConclusionOur data suggested that higher NIHSS scores and large infarction size served as independent predictors of short-term unfavorable outcome, while inflammatory and thrombogenic markers did not.

Highlights

A noticeable increase in the incidence of stroke, a common cause of disability in young adulthood, has been reported
Our data suggested that higher National Institutes of Health Stroke Scale (NIHSS) scores and large infarction size served as independent predictors of short-term unfavorable outcome, while inflammatory and thrombogenic markers did not
Clinical and radiological characteristics of study population The patients presented to the Stroke Unit at Kasr Alainy Hospital within 5 to 22 h from the onset of the neurological deficit

Summary

Introduction

A noticeable increase in the incidence of stroke, a common cause of disability in young adulthood, has been reported. Being the main power of any nation, studying brain ischemia in those victims is of paramount importance in order to establish strategies which might alleviate the psychological and financial burdens on the patients and communities [1]. The current study was conducted to identify independent predictors of short-term outcome of first-ever ischemic stroke in young adults with special emphasis on inflammatory and thrombogenic markers. Exploration of this area might substantially lead to better understanding of the pathophysiology of the disease and emergence of new therapeutic strategies, improving both morbidity and survival. Studying outcome predictors in patients with onset of cerebral infarction in early adult life may enhance our knowledge of disease pathophysiology and prognosis

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