Abstract
This study examined indices of skeletal muscle contraction in a rat model of referred muscle hyperalgesia from artificial ureteric calculosis [left oblique muscle (OE) for ipsilateral stone]. In specimens from the left versus right OE of stone-implanted female rats, a significant increase was found in membrane fluidity ( P<0.01) and Ca 2+-ATPase activity ( P<0.0001) and a significant decrease in 3H-ryanodine binding ( P<0.0001) and in I band length/sarcomere length ratio (contraction index) ( P<0.01). The increase in Ca 2+-ATPase activity was directly and significantly related to the number of rats’ ureteral ‘crises’ ( P<0.02). The results indicate a state of contraction in the hyperalgesic muscle, whose extent correlates to the algogenic activity of the ureteral stone.
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