Abstract
Inactivated tissue culture adapted Rift Valley Fever (RVF) Virus vaccines were prepared usingMontanide oil ISA 201 VG and aluminum hydroxide gel as adjuvants. The prepared vaccines weresterile and safe inducing no systemic or local clinical signs in sheep. Comparative evaluation ofexperimentally prepared vaccines in sheep after a single dose indicated that the oily prepared vaccinesstimulated the humeral immune response as estimated by SNT and ELISA compared with aluminumhydroxide gel vaccine. Protective serum antibody titers against in Montanide oil ISA 201 VGadjuvenated RVF vaccine appeared in protective level at 1st week post vaccination and aluminumhydroxide gel adjuvenated RVF vaccine at 2nd week. This protective titer persisted till 12th month inthe new oily vaccine and till the 6th month for Aluminum hydroxide gel vaccine. Both of SNT andELISA indicated that among the used adjuvant Montanide oil ISA 201 VG was preferable
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
