Abstract
Abstract Background Brucea antidysentrica is traditionally used to treat various conditions. Though, fruits of B. antidysentrica are claimed to promote wound healing; there is no scientific evidence that supports the traditional claim. Therefore, this study was aimed to evaluate the wound healing and anti-inflammatory activities of the extract. Methods Extracts were formulated as 1% and 2% ointments. Simple and nitrofurazone (0.2%) ointments were used as controls for the wound healing. A dose of 100, 200 and 400 mg/kg body weight were used for anti-inflammatory activity tests using vehicle and indomethacin 10 mg/kg as controls. Wound contraction rate, complete epithelialization period, skin breaking strength and edema inhibition were evaluated. Results On last day of treatment, fruits extract showed a significant wound healing activity at strengths of 2% compared with negative control as. On the same day 1% MFE was found to increase the % wound contraction significantly (P Conclusion The extract supports traditional claims for wound healing and anti-inflammatory activity.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
