Evaluation of in vivo anti-inflammatory and analgesic activity of Dillenia indica f. elongata (Miq.) Miq. and Shorea robusta stem bark extracts

Abstract

ObjectiveTo evaluate the in vivo anti-inflammatory and analgesic potential of stem bark extract of Dillenia indica f. elongata (Miq.) Miq. (D. indica f. elongata) and its comparison with Shorea robusta Gaertn. (S. robusta) and respective standard drugs in experimental animals. MethodsAnalgesic models (hot plate, tail flick and formalin induced paw licking) along with acute (carrageenan-induced) and chronic (formalin-induced) models of inflammation were evaluated for analgesic and anti-inflammatory potential of the plant extracts. ResultsThe results of the study showed that the ethyl acetate extracts of D. indica f. elongata (100 and 300 mg/kg) and S. robusta (100 and 300 mg/kg) possessed good central as well as peripheral analgesic activity as compared with pentazocine and indomethacin (10 mg/kg) respectively. The extracts showed significant (P < 0.01) activity in carrageenan- and formalin-induced chronic inflammation models by using indomethacin (8 mg/kg) and diclofenac (13.5 mg/kg) as standard drugs respectively. ConclusionsIt can be concluded that the presence of major constituents like flavonoids, tannins and phenols in the ethyl acetate extracts of stem bark of D. indica f. elongata (100 and 300 mg/kg) and S. robusta (100 and 300 mg/kg) may be responsible for its analgesic and anti-inflammatory activity.