Abstract
In the absence of external stimuli, the nervous system exhibits a spontaneous electrical activity whose functions are not fully understood, and that represents the background noise of brain operations. Spontaneous activity has been proven to arise not only in vivo, but in in vitro neuronal networks as well, following some stereotypical patterns that reproduce the time course of development of the mammalian nervous system. This review provides an overview of in vitro models for the study of spontaneous network activity, discussing their ability to reproduce in vivo - like dynamics and the main findings obtained with each particular model. While explanted brain slices are able to reproduce the neuronal oscillations typically observed in anaesthetized animals, dissociated cultures allow the use of patient-derived neurons and limit the number of animals used for sample preparation.
Highlights
Spontaneous neural oscillations have been observed by researchers as early as the 1930s, when the electroencephalography (EEG) machine was invented [1]
This review provides an overview of in vitro models for the study of spontaneous network activity, discussing their ability to reproduce in vivo - like dynamics and the main findings obtained with each particular model
While explanted brain slices are able to reproduce the neuronal oscillations typically observed in anaesthetized animals, dissociated cultures allow the use of patient-derived neurons and limit the number of animals used for sample preparation
Summary
Evaluation of in vitro neuronal networks for the study of spontaneous activity Diletta POZZIa,b*. A Neurobiology Sector, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy. B Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, 300 Pasteur Drive, 94305 Stanford, California
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