Abstract
Introduction: The use of natural products as anticancer agents has a long history that began with folklore medicine and through the years has been incorporated into traditional and allopathic medicine. Several drugs currently used are derived from medicinal plants.
 Objective: The main objective of this study is to investigate the cytotoxic potential of hepatoprotective polyherbal formulation in normal and cancer cell lines.
 Methods: A 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was utilized to screen the cytotoxic activity.
 Results: The results revealed that the formulation does not induce much mortality in normal liver and kidney cell lines, and LC50 value of liver cell lines was found 1716.355 μg/ml and kidney cell lines 2464.910 μg/ml. The in vitro anticancer activity was performed on liver, colon, and prostate cancer cell lines, and IC50 values are found 2.077, 3.850, and 11.989 μg/ml, respectively, which show excellent anticancer activity.
 Conclusion: Based on the results obtained, the hepatoprotective polyherbal formulation is safe for normal cells and cytotoxic for cancer cells. Further, identification and quantification of phytoconstituents responsible for the activity are in progress.
Highlights
In recent years, most of the world population is witnessing medicine going back to nature - a shift in global trend from synthetic to natural medicine
In vitro cell line models are quite easy to perform in laboratory conditions
Different concentrations of LVR05 were tested against normal liver and kidney cell lines, and the toxicity was assessed
Summary
Most of the world population is witnessing medicine going back to nature - a shift in global trend from synthetic to natural medicine. More research is going on phytomedicine, and several botanical preparations are evaluated for its potential therapeutic efficacy. Among those botanical drugs, anticancer and hepatoprotective agents are standing in front [1]. Most of the oncology-related researchers are trying to identify botanical preparations which show maximum anticancer effect with a minimum side effect. Semisynthetic or isolated active components from botanical origin such as Catharanthus roseus, Taxus brevifolia, Podophyllum emodi, and Camptotheca acuminata have been used in the treatment cancer [3]. The main objective of this study is to investigate cytotoxic potential and anticancer activity of a polyherbal ayurvedic formulation in cell line model
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