Abstract
AbstractCaralluma lasiantha is used as a traditional medicine in India to heal body heat and inflammations. In order to find out a scientific validation for the Indian traditional knowledge, antibacterial activity of C. lasiantha extracts was studied against inflammation causing bacteria (viz., Staphylococcus aureus, Escherichia coli, Streptococcus Sp., Bacillus subtilis, Enterobacter aerogenes, Klebsiella pneumoniae) along with other Gram-positive and Gram-negative bacteria. Solvents with different polarity were used for extraction from dry roots and stems. Minimum inhibitory concentrations (MIC) were also studied. Differential antibacterial activity was exhibited by extracts and higher inhibition potential against Gram-positive bacteria was explained. The observed antibacterial activities were correlated with the chemical structures of phytochemicals present in C. lasiantha. Anti-inflammation activities are related to C. lasiantha extracts through their antibacterial activities.
Highlights
Nowadays, an increase in awareness on traditional medicine is observed due to development of resistance by micro-organisms toward many synthetic antibiotics
Antimicrobial activity of all the C. lasiantha extracts was studied against Gram-positive (B. subtilis, S. aureus, Streptococcus Sp., B. megaterium) and Gram-negative (E. aerogenes, K. pneumoniae, E. coli, P. aeruginosa) bacteria (Tables 1 and 2; Figures 1 and 2)
From the present in vitro studies, it can be concluded that the crude plant extracts of C. lasiantha exhibit good antimicrobial activity against the selected bacteria due to the presence of steroids and flavones in plant extracts
Summary
An increase in awareness on traditional medicine is observed due to development of resistance by micro-organisms toward many synthetic antibiotics. The healing potential of plants is very well known from primeval times. The secondary metabolites produced in plants are responsible for their pharmacological activity [1]. As plants provide a number of drugs, herbal products have been used in the healing of an array of ailments [2]. The need of hour is the screening of local medicinal plants in view of their richness in antimicrobial agents [3].
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