Evaluation of immunoglobulin G and immunoglobulin G subclass levels in serum of antimuscle specific kinase and anti-acetylcholine receptor antibody positive myasthenia gravis patients

Abstract

Due to policy boundaries, the results and conclusions of my thesis cannot be disclosed in this paper. Instead this paper will provide background information about myasthenia gravis (MG) and the role of immunoglobulin G (IgG) antibodies in autoimmune MG. Additionally, previous literature will be discussed to elucidate the aim and relevance of my internship project. During the internship, total IgG and IgG subclass (IgG1, IgG2, IgG3, and IgG4) concentrations were evaluated in serum of anti-muscle specific kinase antibody positive MG (MuSK-MG), anti-acetylcholine receptor antibody positive MG (AChR-MG) patients and compared with the total IgG and IgG subclass levels in healthy control serum.