Evaluation of Ibuprofen Emulsion Formulated Using Moringa Oleifera Seed Oil

Abstract

This study was carried out to evaluate the physicochemical properties of ibuprofen emulsions formulated using Moringa oleifera seed oil as the oil phase. Moringa oleifera seeds were de-hulled, dried ad pulverized into powder. A 100 g quantity was extracted by Sohxlet extraction using petroleum ether. The extracted moringa seed oil was characterized based on refractive index, specific gravity, ash and moisture content. It was used to prepare ibuprofen emulsions using the wet gum method. The prepared emulsions were evaluated based on physicochemical properties such as pH, viscosity and organoleptic properties. The extracted oil was golden yellow in colour with characteristic odour. It has refractive index, density, and specific gravity of 1.461±0.002, 0.92±0.01 g/dm, and 0.92±0.01 respectively. The ash and moisture contents were 2.86% and 6.42% respectively. The pH of the prepared ibuprofen emulsions were between 4. 9±0.00 and 5.2±0.01 even after 4 weeks of stability study. The viscosity of the emulsions ranged from 1500±0.00-2500±0.01 mPas even after 4 weeks stability study. All the emulsions were the oil-in-water type. Stable ibuprofen emulsions were formulated using moringa seed oil as the oil phase and either acacia or Tween 80 as the emulsifying agent. The emulsions were comparable in physicochemical properties and stability to those prepared using arachis oil as the oil phase.