Abstract
To evaluate whether hypoxia inducible factor (HIF-1α) targeting pharmacological drugs, echinomycin, resveratrol and CdCl2 which inhibit HIF-1α stimulation, and mimosine, which enhances the stability of HIF-1α present antileishmanial properties. The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous leishmaniosis. Resveratrol and CdCl2 reduced the parasite load [IC50, (27.3±2.25) μM and (24.8±0.95) μM, respectively]. The IC50 value of echinomycin was (22.7±7.36) nM and mimosine did not alter the parasite load in primary macrophages. The macrophage viability IC50 values for resveratrol, echinomycin and CdCl2 and mimosine were >40μM, >100nM, >200μM and>2000μM, respectively. Invivo no differences between cutaneous lesions from control, resveratrol- and echinomycin-treated Balb/c mice were detected. Resveratrol, echinomycin and CdCl2 reduce parasite survival invitro. The HIF-1α targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies.
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