Abstract
Sickle cell anemia (SCA) is an inherited condition of chronic hemolytic anemia that includes several different genotypes. People with SCA are encouraged to drink extra fluids in order to prevent dehydration that may lead to red cell sickling and consequently more serious problems. Proper hydration is an important factor in maintaining homeostasis in the body; it is necessary to regulate body temperature, maintain energy levels, aid digestion and eliminate toxins.
Highlights
In an adequately hydrated person, overall total body water (TBW) accounts for 55-65% of overall body weight [1]
Bioelectrical Impedence (BIA) results in our study show these children had a deficit of TBW by a mean of 10.6 liters when compared to reference range values for age-matched non-Sickle cell anemia (SCA) children
Poor hydration increases the viscosity of the blood and can impact hem concentration resulting in venous occlusive crisis (VOC) [14]
Summary
In an adequately hydrated person, overall total body water (TBW) accounts for 55-65% of overall body weight [1]. Poor hydration increases the thickness or viscosity of blood. Hypothenuria compounds the risk for dehydration in patients with SCA. When patients with SCA take in too little fluid and too much sodium, this may force water from the red cells and dehydrate the cell, the concentration of sickle hemoglobin increases in the red cell. This increase in sickle hemoglobin can lead to pain crisis
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