Abstract
Patients with NAFLD (non-alcoholic fatty liver disease) and subclinical hypothyroidism are at risk of cardiovascular complications that cause cardiometabolic changes, thus enabling to broaden our understanding of the cardiovascular events risk in a comorbid patient.
 The aim: The study of hormonal and metabolic indicators and cardiovascular risk factors in women from NAFLD combined with SH (subclinical hypothyroidism) depending on the age.
 Materials and methods: 128 patients with NAFLD were studied, which were divided into 2 groups: І group – patients with NAFLD and level of thyroid-stimulating hormone (TSH) – 4 to 10 mIU/mL (n=45), ІІ group - patients with NAFLD and level of TSH >10 mIU/mL (n=49). The control group consisted of 34 NAFLD patients without SH. Depending on the level of TSH and age, degree of cardiovascular risk, indicators of carbohydrate and lipid metabolism, as well as the indicators that reflect ED were evaluated.
 Results: Comparison of metabolic parameters in two groups showed a significant difference (p<0.01 between indicators depending on the TSH level, where patients were below 50 years of age: HbA1c, LDL cholesterol, HDL cholesterol, gamma-glutamyltranspeptidase (GGTP). The levels of CDEC (circulating desquamated endothelial cells), VEGF (vascular endothelial growth factor), CRP (C-reactive protein) and TNF-α (tumor necrosis factor-α) were dependent not only on TSH, but also on age. Significant differences (p=0.001) were obtained in patients aged ≤ 50 years: CDEC; VEGF, CRP; TNF-α.
 Conclusions: Patients from NAFLD combined with SH have hormonal-metabolic disorders, and their degree depends on the TSH level. Early cardiometabolic changes in women are formed already at the age under 50 years, which indicates the formation of early atherosclerotic vascular changes
Highlights
Non-alcoholic fatty liver disease (NAFLD) plays an important part in common non-communicable diseases combining clinicopathologic changes of various degrees: from hepatic steatosis to hepatocellular carcinoma and caused by lifestyle changes [1]
The metabolic changes in the two groups depending on the thyroid-stimulating hormone (TSH) level were associated with the age of the women
The metabolic values depending on the level of TSH in women having NAFLD combined with subcli nical hypothyroidism (SH) aged ≤ 50 years, M ± m
Summary
Non-alcoholic fatty liver disease (NAFLD) plays an important part in common non-communicable diseases combining clinicopathologic changes of various degrees: from hepatic steatosis to hepatocellular carcinoma and caused by lifestyle changes [1]. The current prevalence of NAFLD (2021), «EUREKA: Health Sciences» Number 1 in industrialized countries is estimated at 20 % to 35 % among general population. According to data from 2019, the prevalence of NAFLD in industrialized countries was estimated at 20 % to 35 % among general population. NAFLD develops usually at a young age (30–50 years) among men, and the incidence of NAFLD among women increases after menopause or in accordance with the hyperandrogenism, as a consequence of polycystic ovary syndrome and Cushing’s syndrome. NAFLD in men is associated with a massive amount of visceral fat, larger increase in ALT level and a low level of adiponectin and leptin [4, 5]
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