Abstract
It is known that the pathological course of pregnancy is associated with a disturbance in the interdependent “mother-fetus” complex and leads to specific clinical consequences at the molecular-cellular, tissue, organ, organismal and population levels of organization. In case of violation of placentation (placental barrier), a state of immune conflict occurs, characterized by an antigen-antibody reaction, carried out through the placenta (in relation to the fetus), or through colostrum after birth (in relation to the newborn offspring). Therefore, immunological relations at the population level should be considered both the consequences of the action of the maternal organism’s antigens on the fetus, and the effects of the allogeneic action of the fetus on the mother’s body. According to the results of the experiment, the placentas of 10 sows of Large White breed were used as the material, which showed signs of isoimmunization to the resulting offspring. For histological examination, immediately after delivery, pieces of placenta up to 0.5 cm thick were selected, which were fixed in a 10% aqueous solution of neutral formalin. The fixed material after wiring through alcohols of increasing concentration, xylene, xylene-paraffin, was poured into paraffin. The obtained preparations were stained with conventional methods-hematoxylin and eosin. d (fibrinoid masses).
Highlights
IntroductionConsidering the results of studies conducted by various authors 2-16 , we can conclude that isoimmunization (sensitization) in some cases creates disturbances in placentation in the induction of immunological reactivity
It is known that the pathological course of pregnancy is associated with a disturbance in the interdependent “mother-fetus” complex and leads to specific clinical consequences at the molecularcellular, tissue, organ, organismal and population levels of organization
According to the results of the experiment, the placentas of 10 sows of Large White breed were used as the material, which showed signs of isoimmunization to the resulting offspring
Summary
Considering the results of studies conducted by various authors 2-16 , we can conclude that isoimmunization (sensitization) in some cases creates disturbances in placentation in the induction of immunological reactivity. The effect of previous isoimmunization may be associated with the formation of circulating antibodies 1-17 , which neutralize the antigen administered during the tolerance induction. This is confirmed by the results of a number of authors 6-8 , which showed that the introduction of specific antibodies early after the injection of the antigen, when full tolerance has not yet occurred, has prevented its development. Experimental studies were conducted on sows of a Large White breed on the farms in the Kurskoy district of the Stavropol territory.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
