Abstract
Objective To investigate the correlation between HER2 gene amplification and HER2 protein overexpression. Methods HER2 status in the surgically removed tissues of 80 meningioma cases was evauated by using immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH) meth-ods. Results The percentages of HER2 protein expression and HER2 gene amplification were 32.50% (26/80) and 8.75% (7/80) in 80 patients with meningioma. Among the 80 cases, 10 (12.50%) cases showed HER2 overexpression (+++/++) by IHC and 7 (8.75%) cases showed HER2 amplification by FISH. None case of the 70 cases with low or negative HER2 expression (+ or O) showed HER2 amplifica-tion. Conclusion The correlation between HER2 protein overexpression and HER2 gene amplification is statistically significant. Therefore immunohistochemistry can be regarded as an initial screening method method for HER2 expression status,and then FISH testing should be done as well It is useful for molecular target therapy to detect HER2 expression status in meningioma. Key words: Meningioma; FISH; HER2; Gene amplification
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.