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Abstract
The hepatotoxic effect of aqueous leaves extract of Cassia italica on some liver function parameters was investigated in albino rats. Five groups of the rats were administered the following graded doses of the extract orally: 0, 300, 600, 1500 and 3000 mg/kg bw, for groups 1, 2, 3, 4 and 5 respectively, once daily for 28 days. The serum ALAT, ASAT and ALP levels were found to increase significantly (p<0.05) in all the groups when compared to the control; whereas the serum Albumin levels decreased significantly (p<0.05) in all the groups when compared with the control. There was also a significant increase in Total Bilirubin level (p<0.05) in the groups administered with 3000 and 1500 mg/kg bw, but the reverse was the case in the groups administered with 600 and 300 mg/kg bw of the extract, which showed significant decrease (p<0.05) when compared with the control. These results suggest that, the aqueous leaves extract of Cassia italica has adverse effects on the functional capacities of rat liver.Keywords: Hepatotoxicity, extract, Cassia italic, rats
Highlights
This study evaluated the hepatotoxicity effect of the plant’s aqeous extract on rat liver
All the rats survived after 48 hours of administration of 3000mg/kg body weight of the extract (Table 1)
The result revealed no observable gross negative effects such as salivation, diarrhea, coma or convulsion in the rats administered the various doses of the extract
Summary
This study evaluated the hepatotoxicity effect of the plant’s aqeous extract on rat liver. One animal serves as the control and the four others were administered 3000mg/kg body weight of the extract, orally in a single dose using intubation canola. The animals were reweighed to determine change in weight over the 48 hours period.
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