Abstract
Liver is one of the largest glands of the body and the main site for intense metabolism and excretion. Liver disease is a term for a collection of conditions that adversely affect the cells, tissues, structures, or functions of the liver. Treatment of liver diseses with various drugs develops risk of toxicity. Rubiacordifolia is an herbal plant has, been claimed to have hepatoprotective potentials. The present study was conducted to explore the hepatoprotective activity of aqueous extract of Rubiacordifolia against carbon tetrachloride induced hepatotoxicity in albino rats. This experimental study was conducted after getting approval from institutional animal ethics committee using, routes of Rubiacordifolia in wistar albino rats (150-200g) of either sex. The hepatoprotective activity was evaluated by using histo-pathological examination. Animals were divided in to five groups with six animals in each group. Group-1 was given Normal saline (1ml/kg/day), Group-2 was injected with carbon tetrachloride (1ml/kg) i.p. only once to produce hepatotoxicity. Group-3 and Group-4 were given Rubiacordifolia (100mg/kg and 200mg/kg) orally every morning for 21 days followed by carbon tetrachloride (1ml/kg) i.p on 21st day (respectively).
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