Abstract

Objectives:To evaluate the hepatoprotective activity of ethanolic extract of Cleome viscosa Linn. (Capparidaceae) against carbon tetrachloride (CCI4) induced hepatotoxicity in experimental animal models.Materials and Methods:Leaf powder of Cleome viscosa was extracted with ethanol. The hepatoprotective activity of the extract was assessed in CCI4 induced hepatotoxicity in rats. Various biochemical parameters were estimated and histopathological studies were also performed on rat liver. The hepatoprotective activity was also supported by determining a functional parameter, i.e. thiopental-induced sleep of mice poisoned with CCl4.Results:The test material was found effective as hepatoprotective, through in vivo and histopathological studies. The extract was found to be effective in shortening the thiopental induced sleep in mice poisoned with CCl4. The hepatoprotective effect of ethanolic extract was comparable to that of silymarin, a standard hepatoprotective agent.Conclusion:The results of the present study show that ethanolic extract of Cleome viscosa has significant hepatoprotective activity.

Highlights

  • Cleome viscosa Linn. (Capparidaceae) is a widely distributed herb with yellow flowers and long slender pods containing seeds

  • The presence of jaundice is a cardinal feature of liver disease and its presence usually shows disturbance involving the hepatobiliary system.[14]

  • Carbon tetrachloride is a potent hepatotoxin, and a single exposure to it can rapidly lead to an increase in the level of several enzymes, severe centrizonal necrosis and steatosis.[15]

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Summary

Introduction

Cleome viscosa Linn. (Capparidaceae) is a widely distributed herb with yellow flowers and long slender pods containing seeds. The whole plant is sticky in nature and has a strong odour resembling asafoetida It is found throughout the greater part of India, often in waste places and is known as Hurhur (Hindi) in Indian traditional medicine. This plant is used in various disorders such as diarrhoea, fever, inflammation, liver diseases, bronchitis, skin diseases, and malarial fever. The juice is useful in piles, lumbago and earache.[1] The analgesic, antipyretic and anti-diarrhoeal activities of the extract have been reported by researchers.[2,3,4] In our field studies of ethnomedicinal plants of Bundelkhand, it was noted that the fresh leaves of Cleome viscosa are widely used as medicine for jaundice. A systematic study to assess the action of the plant for liver diseases has not been reported and the present investigations were undertaken

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